Activation of the aryl hydrocarbon receptor improves allergen-specific immunotherapy of murine allergic airway inflammation: a novel adjuvant option?

ABSTRACT:

Background

Allergen-specific immunotherapy (AIT) is able to restore immune tolerance to allergens in allergic patients. However, some patients do not or only poorly respond to current treatment protocols. Therefore, there is a need for deeper mechanistic insights and further improvement of treatment strategies. The relevance of the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, has been investigated in several inflammatory diseases, including allergic asthma. However, its potential role in AIT still needs to be addressed.

Methods

A murine model of AIT in ovalbumin-induced allergic airway inflammation was performed in AhR-deficient (AhR^-/-) and wild-type mice. Furthermore, AIT was combined with the application of the high-affinity AhR ago

SUBMITTER: Heine S 

PROVIDER: S-EPMC11194380 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature