Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape.

ABSTRACT:

Background

Metabolic reprograming and immune escape are two hallmarks of cancer. However, how metabolic disorders drive immune escape in head and neck squamous cell carcinoma (HNSCC) remains unclear. Therefore, the aim of the present study was to investigate the metabolic landscape of HNSCC and its mechanism of driving immune escape.

Methods

Analysis of paired tumor tissues and adjacent normal tissues from 69 HNSCC patients was performed using liquid/gas chromatography-mass spectrometry and RNA-sequencing. The tumor-promoting function of kynurenine (Kyn) was explored in vitro and in vivo. The downstream target of Kyn was investigated in CD8⁺ T cells. The regulation of CD8⁺ T cells was investigated after Siglec-15 overexpression in vivo. An engineering n

SUBMITTER: Zhang XY 

PROVIDER: S-EPMC11194450 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature