The multifunction <i>Coxiella</i> effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery.

ABSTRACT: Intracellular bacterial pathogens divert multiple cellular pathways to establish their niche and persist inside their host. Coxiella burnetii, the causative agent of Q fever, secretes bacterial effector proteins via its Type 4 secretion system to generate a Coxiella-containing vacuole (CCV). Manipulation of lipid and protein trafficking by these effectors is essential for bacterial replication and virulence. Here, we have characterized the lipid composition of CCVs and found that the effector Vice interacts with phosphoinositides and membranes enriched in phosphatidylserine and lysobisphosphatidic acid. Remarkably, eukaryotic cells ectopically expressing Vice present compartments that resemble early CCVs in both morphology and composition. We found that the biogenesis of thes

SUBMITTER: Bienvenu A 

PROVIDER: S-EPMC11194487 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature