KEAP1-NRF2 system regulates age-related spermatogenesis dysfunction.

ABSTRACT:

Purpose

The average fatherhood age has been consistently increasing in developed countries. Aging has been identified as a risk factor for male infertility. However, its impact on various mechanisms remains unclear. This study focused on the KEAP1-NRF2 oxidative stress response system, by investigating the relationship between the KEAP1-NRF2 system and age-related changes in spermatogenesis.

Methods

For examination of age-related changes, we used 10-, 30-, 60-, and 90-week-old mice to compare sperm count, sperm motility, and protein expression. For assessment of Keap1 inhibition, 85-week-old C57BL/6J mice were randomly assigned to the following groups: control and bardoxolone methyl (KEAP1 inhibitor). Whole-exome sequencing of a Japanese cohort of patients with non-obstructi

SUBMITTER: Kuribayashi S 

PROVIDER: S-EPMC11194679 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature