Structure-based design of SARS-CoV-2 papain-like protease inhibitors.

ABSTRACT: The COVID-19 pandemic is caused by SARS-CoV-2, an RNA virus with high transmissibility and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS-CoV-2 infection, there is a critical need for additional antivirals with alternative mechanisms of action. Papain-like protease (PL^pro) is one of the two SARS-CoV-2 encoded viral cysteine proteases essential for viral replication. PL^pro cleaves at three sites of the viral polyproteins. In addition, PL^pro antagonizes the host immune response upon viral infection by cleaving ISG15 and ubiquitin from host proteins. Therefore, PL^pro is a validated antiviral drug target. In this study, we report the X-ray crystal structures of papain-like protease (PL^pro) with two p

SUBMITTER: Jadhav P 

PROVIDER: S-EPMC11194760 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature