Associations of systemic immune-inflammation index with high risk for prostate cancer in middle-aged and older US males: A population-based study.

ABSTRACT:

Background

Systemic immune-inflammation index (SII) provides convincing evaluation of systemic immune and inflammatory condition in human body. Its correlation with prostate cancer (PCa) risk remains uncharted. The principal objective of this investigation was to elucidate the association between SII and the risk for PCa in middle-aged and elderly males.

Materials and methods

Analysis entailed multivariate linear and logistic regression, generalized additive model, and smoothing curve fitting using resource from 2007 to 2010 National Health and Nutrition Examination Survey (NHANES). To ascertain robustness and consistency of this association across different demographic strata, we conducted rigorous subgroup analyses and interaction tests.

Results

Among 3359 participa

SUBMITTER: Yao W 

PROVIDER: S-EPMC11194977 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature