Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation.

ABSTRACT:

Background

There is no reliable indicator that can assess the treatment effect of anticoagulant therapy for sepsis-associated disseminated intravascular coagulation (DIC) in the short term. The aim of this study is to develop and validate a prognostic index identifying 28-day mortality in septic DIC patients treated with antithrombin concentrate after a 3-day treatment.

Methods

The cohort for derivation was established utilizing the dataset from post-marketing surveys, while the cohort for validation was acquired from Japan's nationwide sepsis registry data. Through univariate and multivariate analyses, variables that were independently associated with 28-day mortality were identified within the derivation cohort. Risk variables were then assigned a weighted score based on t

SUBMITTER: Iba T 

PROVIDER: S-EPMC11194983 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature