Eicosapentaenoic and docosahexaenoic acid supplementation and coronary artery calcium progression in patients with coronary artery disease: A secondary analysis of a randomized trial.

ABSTRACT:

Background and aims

We previously reported that an omega-3 fatty acid index ≥4% with high-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) prevented progression of noncalcified plaque. Higher coronary artery calcium (CAC) scores and progression of CAC are associated with increased cardiovascular events and mortality. We examined the effect of EPA + DHA on CAC score.

Methods

A total of 242 patients with coronary artery disease (CAD) on statin therapy were randomized to 1.86 g EPA and 1.5 g DHA daily or none (control) for 30 months. The CAC score was measured at baseline and 30-months with non-contrast, cardiac computed tomography.

Results

Both EPA + DHA and control groups had significant progression in CAC scores over 30 months (median change:183.5 vs 22

SUBMITTER: Hariri E 

PROVIDER: S-EPMC11195009 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature