Evolution of polyamine resistance in <i>Staphylococcus aureus</i> through modulation of potassium transport.

ABSTRACT: Microbes must adapt to diverse biotic and abiotic factors encountered in host environments. Polyamines are an abundant class of aliphatic molecules that play essential roles in fundamental cellular processes across the tree of life. Surprisingly, the bacterial pathogen Staphylococcus aureus is highly sensitive to polyamines encountered during infection, and acquisition of a polyamine resistance locus has been implicated in spread of the prominent USA300 methicillin-resistant S. aureus lineage. At present, alternative pathways of polyamine resistance in staphylococci are largely unknown. Here we applied experimental evolution to identify novel mechanisms and consequences of S. aureus adaption when exposed to increasing concentrations of the polyamine spermine. Evolved p

SUBMITTER: Campbell K 

PROVIDER: S-EPMC11195161 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature