Transcriptomic comparison of in vitro models of the human placenta.

ABSTRACT: Studying the human placenta through in vitro cell culture methods is necessary due to limited access and amenability of human placental tissue to certain experimental methods as well as distinct anatomical and physiological differences between animal and human placentas. Selecting an in vitro culture model of the human placenta is challenging due to representation of different trophoblast cell types with distinct biological roles and limited comparative studies that define key characteristics of these models. Therefore, the aim of this research was to create a comprehensive transcriptomic comparison of common in vitro models of the human placenta compared to bulk placental tissue from the CANDLE and GAPPS cohorts (N=1083). We performed differential gene expression analysis on publicly avai

SUBMITTER: Lapehn S 

PROVIDER: S-EPMC11195179 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature