Combining quantitative proteomics and interactomics for a deeper insight into molecular differences between human cell lines.

ABSTRACT: Cellular functional pathways have evolved through selection based on fitness benefits conferred through protein intra- and inter-molecular interactions that comprise all protein conformational features and protein-protein interactions, collectively referred to as the interactome. While the interactome is regulated by proteome levels, it is also regulated independently by, post translational modification, co-factor, and ligand levels, as well as local protein environmental factors, such as osmolyte concentration, pH, ionic strength, temperature and others. In modern biomedical research, cultivatable cell lines have become an indispensable tool, with selection of optimal cell lines that exhibit specific functional profiles being critical for success in many cases. While it is clear that cell

SUBMITTER: Bakhtina AA 

PROVIDER: S-EPMC11195184 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature