Neuronal identity control at the resolution of a single transcription factor isoform.

ABSTRACT: The brain exhibits remarkable neuronal diversity which is critical for its functional integrity. From the sheer number of cell types emerging from extensive transcriptional, morphological, and connectome datasets, the question arises of how the brain is capable of generating so many unique identities. 'Terminal selectors' are transcription factors hypothesized to determine the final identity characteristics in post-mitotic cells. Which transcription factors function as terminal selectors and the level of control they exert over different terminal characteristics are not well defined. Here, we establish a novel role for the transcription factor broad as a terminal selector in Drosophila melanogaster. We capitalize on existing large sequencing and connectomics datasets and empl

SUBMITTER: Smolin N 

PROVIDER: S-EPMC11195191 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature