Functional Hierarchy of the Human Neocortex from Cradle to Grave.

ABSTRACT: Recent evidence indicates that the organization of the human neocortex is underpinned by smooth spatial gradients of functional connectivity (FC). These gradients provide crucial insight into the relationship between the brain's topographic organization and the texture of human cognition. However, no studies to date have charted how intrinsic FC gradient architecture develops across the entire human lifespan. In this work, we model developmental trajectories of the three primary gradients of FC using a large, high-quality, and temporally-dense functional MRI dataset spanning from birth to 100 years of age. The gradient axes, denoted as sensorimotor-association (SA), visual-somatosensory (VS), and modulation-representation (MR), encode crucial hierarchical organizing principles of the brain

SUBMITTER: Taylor HP 

PROVIDER: S-EPMC11195193 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature