A Path Integral Approach for Allele Frequency Dynamics Under Polygenic Selection.

ABSTRACT: Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotypes. One promising avenue to resolve the genetic basis of complex traits is through evolve-and-resequence experiments, in which laboratory populations are exposed to some selective pressure and trait-contributing loci are identified by extreme frequency changes over the course of the experiment. However, small laboratory populations will experience substantial random genetic drift, and it is difficult to determine whether selection played a roll in a given allele frequency change. Predicting how much allele frequencies change under drift and selection had remained an open problem well into the 21^st century, even those contributing to sim

SUBMITTER: Anderson NW 

PROVIDER: S-EPMC11195211 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature