LAIR1 prevents excess inflammatory tissue damage in <i>S. aureus</i> skin infection and Cutaneous T-cell Lymphoma.

ABSTRACT: Patients with cutaneous T cell lymphoma (CTCL) experience high morbidity and mortality due to S. aureus skin infections and sepsis, but the causative immune defect is unclear. We previously identified high levels of LAIR2, a decoy protein for the inhibitory receptor LAIR1, in advanced CTCL. Mice do not have a LAIR2 homolog, so we used Lair1 knock-out (KO) mice to model LAIR2 overexpression. In a model of subcutaneous S. aureus skin infection, Lair1 KO mice had significantly larger abscesses and areas of dermonecrosis compared to WT. Lair1 KO exhibited a pattern of increased inflammatory responses in infection and sterile immune stimulation, including increased production of proinflammatory cytokines and myeloid chemokines, neutrophil ROS, and collagen/ECM

SUBMITTER: Dorando HK 

PROVIDER: S-EPMC11195265 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature