Escalation of genome defense capacity enables control of an expanding meiotic driver.

ABSTRACT: From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity^1,2. Despite their diversity, different defense pathways share a modular organization, where numerous specificity factors identify diverse targets and common effectors silence them. In the PIWI-interacting RNA (piRNA) pathway, which controls selfish elements in the metazoan germline, diverse target RNAs are first identified by complementary base pairing with piRNAs and then silenced by PIWI-clade nucleases via enzymatic cleavage^1,3. Such a binary architecture allows the defense systems to be readily adaptable, where new targets can be captured via the innovation of new specificity factors^4,5. Thus, our current understan

SUBMITTER: Chen P 

PROVIDER: S-EPMC11195268 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature