The ENCODE mouse postnatal developmental time course identifies regulatory programs of cell types and cell states.

ABSTRACT: Postnatal genomic regulation significantly influences tissue and organ maturation but is under-studied relative to existing genomic catalogs of adult tissues or prenatal development in mouse. The ENCODE4 consortium generated the first comprehensive single-nucleus resource of postnatal regulatory events across a diverse set of mouse tissues. The collection spans seven postnatal time points, mirroring human development from childhood to adulthood, and encompasses five core tissues. We identified 30 cell types, further subdivided into 69 subtypes and cell states across adrenal gland, left cerebral cortex, hippocampus, heart, and gastrocnemius muscle. Our annotations cover both known and novel cell differentiation dynamics ranging from early hippocampal neurogenesis to a new sex-specific adren

SUBMITTER: Rebboah E 

PROVIDER: S-EPMC11195270 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature