Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range.

ABSTRACT: The basic excitatory neurons of the cerebral cortex, the pyramidal cells, are the most important signal integrators for the local circuit. They have quite characteristic morphological and electrophysiological properties that are known to be largely constant with age in the young and adult cortex. However, the brain undergoes several dynamic changes throughout life, such as in the phases of early development and cognitive decline in the aging brain. We set out to search for intrinsic cellular changes in supragranular pyramidal cells across a broad age range: from birth to 85 years of age and we found differences in several biophysical properties between defined age groups. During the first year of life, subthreshold and suprathreshold electrophysiological properties changed in a way that sh

SUBMITTER: Barzo P 

PROVIDER: S-EPMC11195274 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature