Prognostic value of tumor volume doubling time in lung-metastatic adenoid cystic carcinoma.

ABSTRACT:

Objectives

Lung metastases in adenoid cystic carcinoma (ACC) usually have indolent growth and the optimal timing to start systemic therapy is not established. We assessed ACC lung metastasis tumor growth dynamics and compared the prognostic value of time to progression (TTP) and tumor volume doubling time (TVDT).

Methods

The study included ACC patients with ≥1 pulmonary metastasis (≥5 mm) and at least 2 chest computed tomography scans. Radiology assessment was performed from the first scan showing metastasis until treatment initiation or death. Up to 5 lung nodules per patient were segmented for TVDT calculation. To assess tumor growth rate (TGR), the correlation coefficient (r) and coefficient of determination (R²) were calculated for measured lung nodules. TTP w

SUBMITTER: Dal Lago EA 

PROVIDER: S-EPMC11195296 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature