A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic <i>Escherichia coli</i>.

ABSTRACT: The emergence of multidrug-resistant bacteria poses a significant threat to human health, necessitating a comprehensive understanding of their underlying mechanisms. Uropathogenic Escherichia coli (UPEC), the primary causative agent of urinary tract infections, is frequently associated with multidrug resistance and recurrent infections. To elucidate the mechanism of resistance of UPEC to beta-lactam antibiotics, we generated ampicillin-resistant UPEC strains through continuous exposure to low and high levels of ampicillin in the laboratory, referred to as Low Amp^R and High Amp^R, respectively. Whole-genome sequencing revealed that both Low and High Amp^R strains contained mutations in the marR, acrR, and envZ genes. The High Amp

SUBMITTER: Choi N 

PROVIDER: S-EPMC11195483 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature