Major Psychiatric Disorders, Substance Use Behaviors, and Longevity.

ABSTRACT:

Importance

Observational studies suggest that major psychiatric disorders and substance use behaviors reduce longevity, making it difficult to disentangle their relationships with aging-related outcomes.

Objective

To evaluate the associations between the genetic liabilities for major psychiatric disorders, substance use behaviors (smoking and alcohol consumption), and longevity.

Design, settings, and participants

This 2-sample mendelian randomization (MR) study assessed associations between psychiatric disorders, substance use behaviors, and longevity using single-variable and multivariable models. Multiomics analyses were performed elucidating transcriptomic underpinnings of the MR associations and identifying potential proteomic therapeutic targets. This study sourc

SUBMITTER: Rosoff DB 

PROVIDER: S-EPMC11195603 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature