Genome-wide association study of suicidal behaviour severity in mood disorders.

ABSTRACT:

Objective

Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity.

Methods

Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (n = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume.

Results

We did not detect genome-wide significant findings at the single-marker or gene level. We

SUBMITTER: Zai CC 

PROVIDER: S-EPMC11195685 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature