Contractile asymmetry and survival in patients with left bundle branch abnormality treated with cardiac resynchronization therapy.

ABSTRACT:

Aims

Currently, electrical rather than mechanical parameters of delayed left ventricular (LV) activation are used for patient selection for cardiac resynchronization therapy (CRT). However, despite adhering to current guideline-based criteria, about one-third of heart failure (HF) patients fail to derive benefit from CRT. This study sought to investigate the prognostic survival significance of a recently introduced index of contractile asymmetry (ICA) based on the deformation of entire opposing LV walls in the context of selecting patients with HF and left bundle branch abnormality (LBBB) for CRT.

Methods and results

We analysed 367 patients with HF and LBBB undergoing CRT (31.6% females, 69 ± 9 years, ischaemic aetiology in 50.7%, LV ejection fraction 27 ± 6%). ICA was calc

SUBMITTER: Kader N 

PROVIDER: S-EPMC11195769 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature