Microvascular Autoregulation in Skeletal Muscle Using Near-Infrared Spectroscopy and Derivation of Optimal Mean Arterial Pressure in the ICU: Pilot Study and Comparison With Cerebral Near-Infrared Spectroscopy.

ABSTRACT:

Importance

Microvascular autoregulation (MA) maintains adequate tissue perfusion over a range of arterial blood pressure (ABP) and is frequently impaired in critical illness. MA has been studied in the brain to derive personalized hemodynamic targets after brain injury. The ability to measure MA in other organs is not known, which may inform individualized management during shock.

Objectives

This study determines the feasibility of measuring MA in skeletal muscle using near-infrared spectroscopy (NIRS) as a marker of tissue perfusion, the derivation of optimal mean arterial pressure (MAPopt), and comparison with indices from the brain.

Design

Prospective observational study.

Setting

Medical and surgical ICU in a tertiary academic hospital.

Participants

A

SUBMITTER: Mirsajadi A 

PROVIDER: S-EPMC11196085 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature