Drug-Drug Interactions and Their Association with Adverse Health Outcomes in the Older Community-Dwelling Population: A Prospective Cohort Study.

ABSTRACT:

Background

Evidence on associations between drug-drug interactions (DDIs) and health outcomes in the older community-dwelling population is limited.

Objective

We estimate potentially clinically important DDI prevalence and examine the association between DDIs and (1) adverse drug events (ADEs), (2) emergency hospital attendance and (3) health-related quality of life (HRQoL) in an older community-dwelling population in Ireland.

Methods

This is a prospective cohort study of community-dwelling older adults (N = 904) aged ≥ 70 years from 15 general practices in Ireland recruited in 2010 (wave-1) and followed-up over 2 years (wave-2; 2012-2013), with linked national pharmacy claims data. Individuals dispensed two or more drugs (wave-1: N = 842; wave-2: N = 763) were includ

SUBMITTER: Hughes JE 

PROVIDER: S-EPMC11196341 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature