Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated trans-presentation in the carbon tetrachloride-induced liver fibrosis model.

ABSTRACT:

Background

Inflammatory cytokines play key pathogenic roles in liver fibrosis. IL-15 is a proinflammatory cytokine produced by myeloid cells. IL-15 promotes pathogenesis of several chronic inflammatory diseases. However, increased liver fibrosis has been reported in mice lacking IL-15 receptor alpha chain (IL-15Rα), suggesting an anti-fibrogenic role for IL-15. As myeloid cells are key players in liver fibrosis and IL-15 signaling can occur independently of IL-15Rα, we investigated the requirement of IL-15 and IL-15Rα in liver fibrosis.

Methods

We induced liver fibrosis in Il15^-/- , Il15ra^-/- and wildtype C57BL/6 mice by the administration of carbon tetrachloride (CCl₄). Liver fibrosis was evaluated by Sirius red and Mason's tri

SUBMITTER: Cloutier M 

PROVIDER: S-EPMC11196400 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature