Case report: A 53-year-old woman with synchronous WHO classification II and IV gliomas.

ABSTRACT:

Introduction

Glioma is the most common primary intracranial neoplasm with a relatively poor prognosis.

Case presentation

Here, we present a unique case of a 53-year-old woman with two histopathologically distinct gliomas at the initial diagnosis. She presented with headaches and left limb weakness before admission, and magnetic resonance imaging (MRI) showed right frontal and basal ganglia area involvement combined with hemorrhage. The patient underwent a navigation-guided craniotomy for tumor removal. Pathological examination revealed the right frontal lobe lesion as a WHO grade II IDH-NOS astrocytoma, but the right parietal lobe lesion was a WHO grade IV IDH-mutant diffuse astrocytoma. Molecular detection of the parietal lesion revealed a point mutation at the R132 locus o

SUBMITTER: Jia F 

PROVIDER: S-EPMC11196406 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature