Association of circulating vitamin levels with thyroid diseases: a Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have shown conflicting results of vitamins supplementation for thyroid diseases. The causal relationships between vitamins and thyroid diseases are unclear. Therefore, we conducted a two-sample bidirectional Mendelian randomization (MR) study to explore association of circulating vitamin levels with thyroid diseases.

Methods

We performed a bidirectional MR analysis using genome-wide association study (GWAS) data. Genetic tool variables for circulating vitamin levels include vitamins A, B₉, B₁₂, C, D, and E, Genetic tool variables of thyroid diseases include autoimmune hyperthyroidism, autoimmune hypothyroidism, thyroid nodules (TNs), and Thyroid cancer (TC). Inverse-variance weighted multiplicative random effect

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11196410 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature