Elucidating sleep disorders: a comprehensive bioinformatics analysis of functional gene sets and hub genes.

ABSTRACT:

Background

Sleep disorders (SD) are known to have a profound impact on human health and quality of life although their exact pathogenic mechanisms remain poorly understood.

Methods

The study first accessed SD datasets from the GEO and identified DEGs. These DEGs were then subjected to gene set enrichment analysis. Several advanced techniques, including the RF, SVM-RFE, PPI networks, and LASSO methodologies, were utilized to identify hub genes closely associated with SD. Additionally, the ssGSEA approach was employed to analyze immune cell infiltration and functional gene set scores in SD. DEGs were also scrutinized in relation to miRNA, and the DGIdb database was used to explore potential pharmacological treatments for SD. Furthermore, in an SD murine model, the expression l

SUBMITTER: Lin J 

PROVIDER: S-EPMC11196417 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature