PET/CT deep learning prognosis for treatment decision support in esophageal squamous cell carcinoma.

ABSTRACT:

Objectives

The clinical decision-making regarding choosing surgery alone (SA) or surgery followed by postoperative adjuvant chemotherapy (SPOCT) in esophageal squamous cell carcinoma (ESCC) remains controversial. We aim to propose a pre-therapy PET/CT image-based deep learning approach to improve the survival benefit and clinical management of ESCC patients.

Methods

This retrospective multicenter study included 837 ESCC patients from three institutions. Prognostic biomarkers integrating six networks were developed to build an ESCC prognosis (ESCCPro) model and predict the survival probability of ESCC patients treated with SA and SPOCT. Patients who did not undergo surgical resection were in a control group. Overall survival (OS) was the primary end-point event. The expected

SUBMITTER: Song J 

PROVIDER: S-EPMC11196479 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature