Association analysis between the VDR gene variants and type 2 diabetes.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is recognized as a complex metabolic which has affected the lives of millions of people around the world. Vitamin D receptor (VDR) gene polymorphisms have been suggested to be a vital contributor to the development of T2DM. However, the association between VDR gene polymorphisms and T2DM remains controversial. We have investigated the association between two VDR gene polymorphisms (rs731236 and rs1544410) and T2DM in an Iranian population.

Methods

A total of 148 T2DM patients and 100 normal controls were recruited in this study. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis to perform genotyping.

Results

The results of the present research revealed that the frequency of the rs7

SUBMITTER: Salehizadeh S 

PROVIDER: S-EPMC11196562 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature