Unravelling the operation of organic artificial neurons for neuromorphic bioelectronics.

ABSTRACT: Organic artificial neurons operating in liquid environments are crucial components in neuromorphic bioelectronics. However, the current understanding of these neurons is limited, hindering their rational design and development for realistic neuronal emulation in biological settings. Here we combine experiments, numerical non-linear simulations, and analytical tools to unravel the operation of organic artificial neurons. This comprehensive approach elucidates a broad spectrum of biorealistic behaviors, including firing properties, excitability, wetware operation, and biohybrid integration. The non-linear simulations are grounded in a physics-based framework, accounting for ion type and ion concentration in the electrolytic medium, organic mixed ionic-electronic parameters, and biomembrane f

SUBMITTER: Belleri P 

PROVIDER: S-EPMC11196688 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature