Fluorescence-based reagent and spectrum-based optical reader for lactoferrin detection in tears: differentiating Sjogren's syndrome from non-Sjogren's dry eye syndrome.

ABSTRACT: Identification of an early biomarker and effective testing device to differentiate dry eye disease secondary to autoimmune disease (Sjögren's syndrome dry eye disease) from non-Sjögren's dry eye disease are prerequisites for appropriate treatment. We aimed to demonstrate the capacity of a new photo-detection device to evaluate tear lactoferrin levels as a tool for differentiating systemic conditions associated with dry eye disease. Patients with non-Sjögren's and Sjögren's syndrome dry eye disease (n = 54 and n = 52, respectively) and controls (n = 11) were enrolled. All participants completed the Ocular Surface Disease Index questionnaire. Tear collection was performed with Schirmer test, and tear break-up time was examined using a slit lamp. Tear lactoferrin was evaluated using our newly

SUBMITTER: Tsai CY 

PROVIDER: S-EPMC11196714 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature