Discernible interindividual patterns of global efficiency decline during theoretical brain surgery.

ABSTRACT: The concept of functional localization within the brain and the associated risk of resecting these areas during removal of infiltrating tumors, such as diffuse gliomas, are well established in neurosurgery. Global efficiency (GE) is a graph theory concept that can be used to simulate connectome disruption following tumor resection. Structural connectivity graphs were created from diffusion tractography obtained from the brains of 80 healthy adults. These graphs were then used to simulate parcellation resection in every gross anatomical region of the cerebrum by identifying every possible combination of adjacent nodes in a graph and then measuring the drop in GE following nodal deletion. Progressive removal of brain parcellations led to patterns of GE decline that were reasonably predictabl

SUBMITTER: Yueh-Hsin L 

PROVIDER: S-EPMC11196730 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature