Gestational intermittent hypoxia reduces mandibular growth with decreased Sox9 expression and increased Hif1a expression in male offspring rats.

ABSTRACT:

Introduction

Maternal obstructive sleep apnea (OSA) during pregnancy is the risk factor for impaired fetal growth with low birth weight in the offspring. However, it is unclear whether gestational intermittent hypoxia (IH, a hallmark of maternal OSA) has long-term detrimental consequences on the skeletal development of offspring. This study aimed to investigate postnatal maxillofacial bone growth and cartilage metabolism in male and female offspring that were exposed to gestational IH.

Methods

Mother rats underwent IH at 20 cycles/h (nadir, 4% O₂; peak, 21% O₂; 0% CO₂) for 8 h per day during gestational days (GD) 7-20, and their male and female offspring were analyzed postnatally at 5 and 10 weeks of age. All male and female offspring were bo

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC11196756 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature