Association between IGF-1 levels and MDD: a case-control and meta-analysis.

ABSTRACT:

Purpose

Insulin-like growth factor-1 (IGF-1) has a variety of neurotrophic effects, including neurogenesis, remyelination and synaptogenesis, and is an effective regulator of neuronal plasticity. Although multiple studies have investigated IGF-1 in depression-related disorders, few studies have focused on patients with a first episode of clearly diagnosed depression who had never used antidepressants before. Therefore, this study investigated first-episode and drug-naïve patients with depression to supplement the current evidence around IGF-1 levels in depressive disorders.

Patients and methods

This study consisted of two parts. In the first part, 60 patients with first-episode and drug-naïve depression and 60 controls matched for age, sex, and BMI were recruited from the ou

SUBMITTER: Qiao X 

PROVIDER: S-EPMC11196772 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature