NOD2 activation enhances macrophage Fcγ receptor function and may increase the efficacy of antibody therapy.

ABSTRACT:

Introduction

Therapeutic antibodies have become a major strategy to treat oncologic diseases. For chronic lymphocytic leukemia, antibodies against CD20 are used to target and elicit cytotoxic responses against malignant B cells. However, efficacy is often compromised due to a suppressive microenvironment that interferes with cellular immune responses. To overcome this suppression, agonists of pattern recognition receptors have been studied which promote direct cytotoxicity or elicit anti-tumoral immune responses. NOD2 is an intracellular pattern recognition receptor that participates in the detection of peptidoglycan, a key component of bacterial cell walls. This detection then mediates the activation of multiple signaling pathways in myeloid cells. Although several NOD2 agonists a

SUBMITTER: Merchand-Reyes G 

PROVIDER: S-EPMC11196781 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature