Nicotine and fluoxetine alter adolescent dopamine-mediated behaviors via 5-HT_1A receptor activation.

ABSTRACT:

Introduction

Abuse or misuse of tobacco, e-cigarettes, or antidepressants may have serious clinical consequences during adolescence, a sensitive period during brain development when the distinct neurobiology of adolescent serotonin (5-HT) and dopamine (DA) systems create unique behavioral vulnerabilities to drugs of abuse.

Methods

Using a pharmacological approach, we modeled the behavioral and neurochemical effects of subchronic (4-day) nicotine (60µg/kg, i.v.) or fluoxetine (1mg/kg, i.v.) exposure in adolescent and adult male rats.

Results

Nicotine and fluoxetine significantly enhance quinpirole-induced locomotor activity and initial cocaine self-administration in adolescents, but not adults. These effects were blocked by serotonin 5-HT_1A receptor antagoni

SUBMITTER: Yuan M 

PROVIDER: S-EPMC11196788 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature