Analysis of single nucleotide polymorphisms of the metabotropic glutamate receptors in a transgender population.

ABSTRACT:

Introduction

Gender incongruence (GI) is characterized by a marked incongruence between an individual's experienced/expressed gender and the assigned sex at birth. It includes strong displeasure about his or her sexual anatomy and secondary sex characteristics. In some people, this condition produces a strong distress with anxiety and depression named gender dysphoria (GD). This condition appears to be associated with genetic, epigenetics, hormonal as well as social factors. Given that L-glutamate is the major excitatory neurotransmitter in the central nervous system, also associated with male sexual behavior as well as depression, we aimed to determine whether metabotropic glutamate receptors are involved in GD.

Methods

We analyzed 74 single nucleotide polymorphisms located

SUBMITTER: Fernandez R 

PROVIDER: S-EPMC11196815 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature