Progression of cardiac structure and function in people with human immunodeficiency virus.

ABSTRACT:

Objective

People living with HIV (PLWH) are at increased risk for cardiac dysfunction. It is unknown how their global longitudinal cardiac function, cardiac structure, and other indices of function progress over time. We aimed to characterize the longitudinal trend in cardiac structure and function in PLWH.

Design

Retrospective study of PLWH with clinically obtained echocardiograms at an academic medical center.

Methods

We reviewed archived transthoracic echocardiograms (TTEs) performed between 2001 and 2012 on PLWH. The primary outcome measures were progression of global longitudinal strain (GLS, left and right ventricles), LV mass, E/e' ratio, LV end-systolic, and -diastolic volumes using hierarchical mixed model analysis as a function of CD4+ T cell count and HIV R

SUBMITTER: Bloomfield GS 

PROVIDER: S-EPMC11196839 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature