Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants.

ABSTRACT:

What is already known about this topic?

Chlorinated organophosphate flame retardants (Cl-OPFRs) are frequently detected chemicals in the environment and biological samples, yet there is a lack of systematic evaluation regarding the adverse effects and toxicological mechanisms of Cl-OPFRs.

What is added by this report?

This study utilizes the adverse outcome pathway (AOP) framework to assess the health implications and mechanisms of Cl-OPFRs, identifying multi-system toxicity, with a particular emphasis on reproductive issues and the possible toxic mechanisms.

What are the implications for public health practice?

These results enhance knowledge of the health hazards linked to Cl-OPFRs, supporting the creation of focused risk evaluations and suitable regulatory actions.

SUBMITTER: Zhou M 

PROVIDER: S-EPMC11196873 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature