Synthesis of substituted triazole-pyrazole hybrids using triazenylpyrazole precursors.

ABSTRACT: A synthesis route to access triazole-pyrazole hybrids via triazenylpyrazoles was developed. Contrary to existing methods, this route allows the facile N-functionalization of the pyrazole before the attachment of the triazole unit via a copper-catalyzed azide-alkyne cycloaddition. The developed methodology was used to synthesize a library of over fifty new multi-substituted pyrazole-triazole hybrids. We also demonstrate a one-pot strategy that renders the isolation of potentially hazardous azides obsolete. In addition, the compatibility of the method with solid-phase synthesis is shown exemplarily.

SUBMITTER: Graßle S 

PROVIDER: S-EPMC11196952 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature