Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver.

ABSTRACT:

Background

Resection of colorectal liver metastasis is the standard of care for patients with Stage IV CRC. Despite undoubtedly improving the overall survival of patients, pHx for colorectal liver metastasis frequently leads to disease recurrence. The contribution of this procedure to metastatic colorectal cancer at a molecular level is poorly understood. We designed a mouse model of orthograde metastatic colorectal cancer (CRC) to investigate the effect of partial hepatectomy (pHx) on tumor progression.

Methods

CRC organoids were implanted into the cecal walls of wild type mice, and animals were screened for liver metastasis. At the time of metastasis, 1/3 partial hepatectomy was performed and the tumor burden was assessed longitudinally using MRI. After euthanasia, differe

SUBMITTER: Luenstedt J 

PROVIDER: S-EPMC11196966 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature