Multimodal imaging of the role of hyperglycemia following experimental subarachnoid hemorrhage.

ABSTRACT: Hyperglycemia has been linked to worsening outcomes after subarachnoid hemorrhage (SAH). Nevertheless, the mechanisms involved in the pathogenesis of SAH have been scarcely evaluated so far. The role of hyperglycemia was assessed in an experimental model of SAH by T₂ weighted, dynamic contrast-enhanced magnetic resonance imaging (T₂W and DCE-MRI), [¹⁸F]BR-351 PET imaging and immunohistochemistry. Measures included the volume of bleeding, the extent of cerebral infarction and brain edema, blood brain barrier disruption (BBBd), neutrophil infiltration and matrix metalloprotease (MMP) activation. The neurofunctional outcome, neurodegeneration and myelinization were also investigated. The induction of hyperglycemia increased mortality, the size of the ischemic

SUBMITTER: Joya A 

PROVIDER: S-EPMC11197138 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature