Cerebrovascular CO₂ reactivity and dynamic cerebral autoregulation through the eighth decade of life and their implications for cognitive decline.

ABSTRACT: Aging is accompanied by a decrease in cerebral blood flow (CBF), especially in the presence of preclinical cognitive decline. The role of cerebrovascular physiology including regulatory mechanisms of CBF in processes underlying aging and subclinical cognitive decline is, however, not fully understood. We explored changes in cerebrovascular CO₂ reactivity and dynamic cerebral autoregulation (dCA) through the eighth decade of life, and their relation with early cognitive decline. After 10.9 years, twenty-eight (age, 80.0 ± 3.5 years; 46% female) out of forty-eight healthy older adults who had participated in a previous study (age at baseline, 70 ± 4 years; 42% female), underwent repeated transcranial Doppler assessments. Linear mixed-model analyses revealed small reductions in cer

SUBMITTER: Weijs RW 

PROVIDER: S-EPMC11197147 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature