Cross-species transcriptomics identifies obesity associated genes between human and mouse studies.

ABSTRACT:

Background

Fundamentally defined by an imbalance in energy consumption and energy expenditure, obesity is a significant risk factor of several musculoskeletal conditions including osteoarthritis (OA). High-fat diets and sedentary lifestyle leads to increased adiposity resulting in systemic inflammation due to the endocrine properties of adipose tissue producing inflammatory cytokines and adipokines. We previously showed serum levels of specific adipokines are associated with biomarkers of bone remodelling and cartilage volume loss in knee OA patients. Whilst more recently we find the metabolic consequence of obesity drives the enrichment of pro-inflammatory fibroblast subsets within joint synovial tissues in obese individuals compared to those of BMI defined 'health weight'. As suc

SUBMITTER: Acharjee A 

PROVIDER: S-EPMC11197204 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature