S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis.

ABSTRACT:

Background

Juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of conditions that can cause marked disability and diminished quality of life. Data on predictors of clinical response are insufficient to guide selection of the appropriate biologic agent for individual patients. This study aimed to investigate the propensity of S100A8/9 and S100A12 as predictive biomarkers of abatacept response in polyarticular-course juvenile idiopathic arthritis (pJIA).

Methods

Data from a phase 3 trial (NCT01844518) of subcutaneous abatacept in patients with active pJIA (n = 219) were used in this exploratory analysis. Association between biomarker levels at baseline and improvements in JIA-American College of Rheumatology (ACR) criteria responses or baseline disease activity

SUBMITTER: Brunner HI 

PROVIDER: S-EPMC11197242 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature