Lung cancer metabolomics: a pooled analysis in the Cancer Prevention Studies.

ABSTRACT:

Background

A better understanding of lung cancer etiology and the development of screening biomarkers have important implications for lung cancer prevention.

Methods

We included 623 matched case-control pairs from the Cancer Prevention Study (CPS) cohorts. Pre-diagnosis blood samples were collected between 1998 and 2001 in the CPS-II Nutrition cohort and 2006 and 2013 in the CPS-3 cohort and were sent for metabolomics profiling simultaneously. Cancer-free controls at the time of case diagnosis were 1:1 matched to cases on date of birth, blood draw date, sex, and race/ethnicity. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression, controlling for confounders. The Benjamini-Hochberg method was used to correct for multiple c

SUBMITTER: Tang Z 

PROVIDER: S-EPMC11197282 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature