Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis.

ABSTRACT:

Background

The intermediate filament protein vimentin is widely recognized as a molecular marker of epithelial-to-mesenchymal transition. Although vimentin expression is strongly associated with cancer metastatic potential, the exact role of vimentin in cancer metastasis and the underlying mechanism of its pro-metastatic functions remain unclear.

Results

This study revealed that vimentin can enhance integrin β1 surface expression and induce integrin-dependent clustering of cells, shielding them against anoikis cell death. The increased integrin β1 surface expression in suspended cells was caused by vimentin-mediated protection of the internal integrin β1 pool against lysosomal degradation. Additionally, cell detachment was found to induce vimentin Ser38 phosphorylation, allo

SUBMITTER: Jang J 

PROVIDER: S-EPMC11197373 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature