Cardiovascular Risk Factors in Childhood and Adulthood and Cardiovascular Disease in Middle Age.

ABSTRACT:

Importance

Recent evidence suggests that childhood levels of serum lipids, blood pressure, body mass index (BMI), and smoking contribute to adult risk of cardiovascular disease (CVD). Evidence is lacking on whether this is independent of adult risk levels.

Objective

To quantify direct and indirect effects of childhood risk factors on adult CVD via adulthood risk factors using mediation analysis, and to quantify their relative importance during different life-course stages using a life-course approach.

Design, setting, and participants

This prospective cohort study followed participants from the US, Finland, and Australia from childhood (1970s-1990s) until 2019, with data on CVD risk factors in childhood and adulthood. Longitudinal childhood and adulthood risk factors

SUBMITTER: Kartiosuo N 

PROVIDER: S-EPMC11197443 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature